学術論文

基本情報

氏名 田村 優樹
氏名(カナ) タムラ ユウキ
氏名(英語) TAMURA Yuki

名称

Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle

単著・共著の別

共著

発表年月

2016/06

発表雑誌又は発表学会等の名称

Applied Physiology, Nutrition and Metabolism

概要

To examine the potential role of lactate as a signalling molecule in skeletal muscle, we performed global gene expression analysis of the mouse gastrocnemius muscle, 3 h after lactate administration using the Affymetrix GeneChip system (Affymetrix, Santa Clara, Calif., USA). Among the top 15 genes with the largest fold change, increased expression of Ppargc1a, Pdk4, and Ucp3 was confirmed using real-time quantitative polymerase chain reaction. Our findings suggest that lactate serves as a signal for upregulating genes related to mitochondrial function.

共著者

Yu Kitaoka, Kohei Takeda, Yuki Tamura, and Hideo Hatta

掲載ページ数

41, 695-698